Calculation Formula
5-year risk of MAE = 1 − (0.99600731958437)exp(PI)
PI is the sum of each parameter multiplied by its coefficient:
- 0.8605 × Male sex
- 1.6967 × LVEF <45%
- 1.1288 × Nonsustained ventricular tachycardia
- 0.6929 × Septal LGE
- 0.2275 × Ring-like pattern LGE
- 1.5336 × Pathogenic/likely pathogenic variants in "high-risk" genesa
- 2.7535 × Myocardial inflammationb
Each variable equals 1 if present, otherwise 0. The constant 0.99600731958437 represents the baseline survival.
a "High-risk" genes = LMNA, FLNC, TMEM43, PLN, DSP, and RBM20.
b Myocardial inflammation = ESC criteria by endomyocardial biopsy and/or updated Lake Louise criteria by CMR.